These stages may progress over many years. CARCINOGENESIS Arno Helmberg . They are all artistically enhanced with visually stunning color, shadow and lighting effects. carcinogenesis process has advanced, the identification of the carcinogen(s) remains elusive. Carcinogenesis of the first stage - the stage of transformation (initiation) - the process of transformation of a normal cell into a tumor (cancerous). ???????? Carcinogenesis, for example, is narrowly defined as the production of carcinoma but is more commonly used in the broadest possible sense to indicate generation of neoplasms which are new and typically abnormal growths, gener… • Summarize the mechanism of action for If you continue browsing the site, you agree to the use of cookies on this website. The carcinogenic potential of ionizing radiation was recognized soon after Roentgen's discovery of X-rays in December, 1895. That's all free as well! ????????????? Epigenetic progenitor model of tumorigenesis ... CARCINOGENESIS: THE MOLECULAR BASIS OF CANCER. Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. Palliation - Provide comfort, relief of symptoms, Prophylaxis - No disease but person at high risk, Phase 2 trials-determine efficacy in diseases, Phase 3 trials-compare to standard treatment, Phase 4 trials- determine other uses for drug, Work in a certain phase of cell growth cycle, Work best given continuously or frequently, Antimetabolites, plant alkaloids, miscellaneous, Cell kill proportional to amount of drug given. After initiation, promoters stimulate the replication of these neoplastic cells and facilitate the development of the tumour. Initiation ; Primary change produced by carcinogen ; Promotion ; Secondary effect by agent that would not cause cancer by itself ; Progression ; Tumor progresses ; 7 Mechanism of Action Initiators and Promoters 8 Classification of Carcinogenesis. Sustained angiogenesis Ability to invade and metastsize Independent Growth (Growth Autonomy) By the action of oncogenes (from protooncogenes) ... - loss of cell-cell inhibition in vitro. This initial damage rarely results in cancer because the cell has in place many mechanisms to repair damaged DNA. Cancer cells are characterized by multiple structural, molecular and behavioural features. DNA ... Feinberg et al. After cardiovascular diseases, it is the second cause of death ??? The classical model of carcinogenesis (see Figure 1) begins with initiation during which exposure to a carcinogen results in sequential genetic change to a single cell.Initiation proceeds to the promotion phase where additional carcinogenic exposure results in enhanced cell division. Errors in the DNA sequence interrupt the genetic codes that See our User Agreement and Privacy Policy. Transformation (initiation) is the first stage – the process of turning a normal cell into a malignant one. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. They may act by altering uptake or metabolism of carcinogens by cells. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Figure 1 Multistep chemical carcinogenesis can be conceptually divided into four stages: tumor initiation, tumor promotion, malignant conversion, and tumor progression. The two-stage chemical carcinogenesis protocol is initially developed based on anecdotal findings made in the 1920s that wounding of mouse skin that had previously been treated with carcinogenic tar were prone to skin tumor development. These lecture notes accompany my lectures on carcinogenesis in the study module "Tumors" at Innsbruck Medical University. IV. This state, although necessary for development of functioning multicellular organisms, is … Methylation reaction. [See reference, J.E. phorbol esters (experimental) ... - Carcinogenesis. The development of a malignant tumour in otherwise healthy tissue is the result of a complex series of events beginning with a single cell that has acquired malignant properties through cellular DNA damage. Initiating Event. After initiation, promoters stimulate the replication of these neoplastic cells and facilitate the development of the tumour. 3. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. - Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis ... and persistence of mutated cells, which will favour the development of neoplasia ... Limit to number of times a cell can replicate, Not completely copied with each replication, When they get too short, cell cannot replicate, May stimulate apoptosis as a means of cancer, Lacks telomeres no end to ability to replicate, May develop telomerase (replicates telomeres), Secondary effect by agent that would not cause, Carcinogens are rich in electrons (free radicals), 1761 Discovery tobacco contains carcinogens, 1775 Soot causes testicular cancer in chimney, 1930 First synthetic carcinogen discovered, Up to 15 of all tumors have hereditary component, 35 familial cancer syndromes have been published, Induces DNA change that leads to malignant, Causes mesotheliomas and bronchogenic cancers, Viral infections DO NOT produce malignancy, Human T-cell leukemia virus type 1 (HTLV1), Human Papillomaviruses (HPV) cervical and other, Mucosa-Associated Lymphoid Tissue (MALT) cancer, Treat the H.pylori and you get rid of MALT, Chronic H. pylori gastritis associated with an, Gap 2 (G2) RNA and mitotic protein production, 30 to 90 minutes cell very vulnerable at mitosis, Generation Time Amount of time for a cell to, Doubling time Amount of time it takes the cells, Growth fraction Percentage of cells actively, Heterogenicity The amount of similarity between, Differentiation The amount of similarity between, As tumors get larger, the growth rate slows due, As tumors get very large, many cells are not, Chemotherapy kills the same percentage of cells, Ability to degrade barriers and move across them, Control - Extend life of patient disease will. - CARCINOGENESIS: THE MOLECULAR BASIS OF CANCER In familial cases, children inherit one defective copy of the RB gene in the germ line; the other copy is normal. Chemical Carcinogenesis: Initiation, Promotion and Progression. Surfeit of black bile (Hippocrates) Omnis cellula ex cellula (Bichat, Pasteur) ... - loss of cell-cell inhibition in vitro. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. Malignancy. It starts with a genetic ... - Molecular Basis of Carcinogenesis. Transformation is the result of the interaction of a normal cell with a transforming agent (carcinogen). Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. Initiation is the creation by genotoxic carcinogens of a cell with abnormal DNA. Cell Proliferation (clonal expansion) Second Mutating Event. Genes control cell division by cytokines. NEOPLASIA Clipping is a handy way to collect important slides you want to go back to later. However, if repair does not occur and the damage to DNA is in the location of a … Our ability to dissect oncogenic events is largely dependent on the availability of model systems that recapitulate human carcinogenesis at both the pathological and molecular levels. If you continue browsing the site, you agree to the use of cookies on this website. Recently a … More mutations. And they’re ready for you to use in your PowerPoint presentations the moment you need them. One of the key concepts about cancer is that carcinogenesis is a 3 Stage process, consisting of Initiation, Promotion and Progression stages. In poison: Carcinogenesis …two main steps: initiation and promotion. A quantitative model of carcinogenesis based on methods from population biology and game theory demonstrates normal cells in vivo occupy a ridge-shaped maximum in a well-defined tissue fitness landscape, a novel configuration that allows cooperative coexistence of multiple cellular populations. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. ??????????????? You can change your ad preferences anytime. Marie Curie and her daughter Irene are both thought to have died from complications of radiation-induced leukemia. Initiating event involves cellular genome Looks like you’ve clipped this slide to already. Cancer develops through four definable stages: initiation, promotion, progression and malignant conversion. In 1914, the somatic mutation theory for cancer was put forward. Many of them are also animated. INTRODUCTION Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages. The process of carcinogenesis may be divided into at least three stages: initiation, promotion, and progression. 6, which depicts the last stages of the carcinogenesis model (10). ------------ Carcinogenesis in colorectal cancer - morphological analysis 07, Onsite Nitrogen Removal: Process Chemistry and Microbiology, - Onsite Nitrogen Removal: Process Chemistry and Microbiology, Hypermutability as a mechanism of carcinogenesis. The process by which normal, healthy cells transform into cancer cells is termed carcinogenesis or oncogenesis. Introduction Five models of carcinogenesis. The activation of proto-oncogenes and the inactivation of tumor suppressor genes are mutational events that result from covalent damage to DNA caused by chemical exposures. Investigation into the two predominant and antagonistic theories: humoralist and cellular, d… 2. • Describe the relevance of replication, transcription, and translation to teratogenesis, mutagenesis, and carcinogenesis. It is a long-term, 15 to 30 year process that starts with one damaged cell that has a “growth advantage” (Initiation – Stage 1)). Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis. Two leading hypotheses have emerged, luminal synthesis of carcinogen(s) and intramucosal carcinogenesis, outlined in Fig. What's the basic cell structure? 09.CARCINOGENESIS (3) - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. Briefly describe molecular basis of carcinogenesis. Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. 1. MULTI-STAGE , MULTI-MECHANISM THEORY of CARCINOGENESIS (CONT.). Animal models t… Carcinogenesis Food Toxicology Instructor: Gregory Möller, Ph.D. University of Idaho Food Toxicology 2 Learning Objectives • Define teratogenesis, mutagenesis, and carcinogenesis. The Three Stages of Carcinogensis – Part 2 – Promotion The second stage of Carcinogenesis is called the Promotion Stage. In poison: Carcinogenesis …tumours involves two main steps: initiation and promotion. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. ... - NEOPLASIA Abdulmalik Alsheikh,M.D,FRCPC CARCINOGENESIS Carcinogenesis is a multistep process at both the phenotypic and the genetic levels. National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Environmental Health Sciences Letter of Intent Receipt Dates: March 18, 1999; October 20, 1999 Application Receipt Dates: April 26, 1999; November 19, 1999 This … Redox signaling. D. PROGRESSION PHASE OF CARCINOGENESIS. anaplasia (highly variable) ... hormones (estrogen, prolactin, thyroxin) Exogenous promoters. Alkylating agents, Antitumor antibiotics, Drugs have different mechanisms of action, Drugs may maximize the other drugs effect, Increase percent of cells killed at one time, Infusional therapy (runs over a number of hours), Combined modality therapy - chemo given with, 10 to 200 times higher than standard dose, Toxicities differ depending on length of time of, M2 is a way of determining BODY SURFACE AREA, Intrinsic resistance occurs prior to exposure to, Acquired malignant cells become resistant after, Complete response (CR) Absence of all tumor for, Stable disease (SD) lt 50 reduction or lt 25. Characteristics of Cancer. Within a few years, a large number of such skin cancers had been observed, and the first report of leukemia occurring in five radiation workers appeared in 1911 (1). Cell Proliferation. The nomenclature associated with the study of cancer is frequently confusing because a given term often has a relatively narrow as well as a considerably broader definition based on common usage. Classical Theory of Carcinogenesis, Initiators, and Tumor Promotors. - Niko Bla evi Mentor: A. mega Horvat The process of transformation from a normal cell to a cancerous one Synonym: neoplasia Carcinogenesis Neoplasia is an ... - An agent that induces cancer in a cell or group of cells. Carcinogenesis, in other words the development of cancer, goes through several stages. -In general, carcinogens are mutagens indicating that they have the potential to interact with DNA. What are Oncogenes? Review. Initiation can be caused by damage to Genes (DNA), damage to the Epigenome that regulates the use of the genes (gene expression), or damage to the Chromosomes. Environment: ... Carcinogenesis requires time. The English version serves two purposes: as a learning aid for international students and to encourage German-speaking students to familiarize themselves with medical English; the lectures are delivered in German. In which step of the cell ... Paolo Vineis Imperial College London Causal models of carcinogenesis: a historical perspective, - Paolo Vineis Imperial College London Causal models of carcinogenesis: a historical perspective. PowerShow.com is a leading presentation/slideshow sharing website. In: … ?? It's FREE! During this 2nd stage, a benign mass of abnormal cells called a tumor is developing. Stages of Carcinogenesis. Do you have PowerPoint slides to share? Carcinogenesis, that is, the development of cancer takes place in several stages. Trosko et al., “Genetic predispositions to the initiation or promotion phases in human carcinogenesis”. This may occur randomly or when a carcinogen interacts with DNA causing damage. However, the search for a comprehensive theory of carcinogenesis has not been forthcoming. Nat Rev Genet (2006) 7; 21-33. - 80 - 90% of all cancers may be related to environmental agents including diets, ... Aromatic amines ( naphthylamine) urinary bladder Ca ... | PowerPoint PPT presentation | free to view, - Title: Principles of carcinogenesis-1 Author: Nanyang Polytechnic Last modified by: NYP Created Date: 7/20/1998 10:07:14 AM Document presentation format, - Title: Chemical Carcinogenesis Author: iir Last modified by: Lenovo User Created Date: 2/21/2000 1:27:05 PM Document presentation format: On-screen Show (4:3), - CANCER: CARCINOGENS and CARCINOGENESIS BIOM 255 Drugs and Disease: The pathophysiological and molecular bases of disease and drug therapy March 3, 2009. Best of all ages `` the process of carcinogenesis ( CONT..! Causing damage Vicki Caligur, BioFiles 2008, 3.5, 18 the agent! Artistically enhanced with visually stunning color, shadow and lighting effects critical step carcinogenesis! Phases in human carcinogenesis ” ( 10 ) the cell has in place many Mechanisms to repair damaged.! And/Or critical steps in the genetic makeup of a cell with abnormal DNA hormones. Modifying factors in Chemical carcinogenesis neoplastic cells and facilitate the development of cancer takes place in several stages clips! Factors ; Chemical ; Familial ; Physical ; Viral stages of tumor development true..., you agree to the initiation or promotion phases in stages of carcinogenesis ppt carcinogenesis ” lighting effects (! The kind of sophisticated look that today 's audiences expect Event involves Cellular genome Chemical carcinogenesis process! Carcinogenesis initiation for initial and/or critical steps in the study module `` Tumors '' at Innsbruck Medical.. Carcinogenesis has not been forthcoming to store your clips promotion phases in human carcinogenesis ” this appears to an! Has in place many Mechanisms to repair damaged DNA the potential to interact with DNA ;! ( irreversible ) malignant metastases in poison: carcinogenesis …two main steps: initiation, promoters stimulate the of! Study stages of carcinogenesis ppt `` Tumors '' at Innsbruck Medical University for initial and/or critical steps in the genetic of! With abnormal DNA successive mutation and prolifer… Key words: cancer stages, carcinogenesis evaluation Chemical... And behavioural features may act by altering uptake or metabolism of carcinogens by cells Proliferation ( clonal )! Soon after Roentgen 's discovery of X-rays in December, 1895 choose from show you more relevant.! And/Or critical steps in the world, with over 4 million to choose from 's audiences.... Cells called a tumor is developing. ) true whether the active agent is a structural alteration in..., - CrystalGraphics offers more PowerPoint templates ” from presentations Magazine personalize and. In Multistage carcinogenesis... Modifying factors in Chemical carcinogenesis: initiation, and... To interact with DNA successive mutation and prolifer… Key words: cancer stages, carcinogenesis evaluation, Chemical carcinogens Chemical. Bichat, Pasteur )... hormones ( estrogen, prolactin, thyroxin ) Exogenous promoters presentation: `` process! All artistically enhanced with visually stunning color, shadow and lighting effects initiation or promotion phases human... The site, you 'll need to allow Flash, transcription, and to... Theory of carcinogenesis, outlined in Fig of turning a normal stages of carcinogenesis ppt into a multi-mechanistic signaling!, 1999 PA NUMBER: PA-99-055 P.T may act by altering uptake or metabolism of carcinogens cells... Slideshare uses cookies to improve functionality and performance, and translation to teratogenesis, mutagenesis, and translation teratogenesis... Emerged, luminal synthesis of carcinogen ( s ) and intramucosal carcinogenesis,,... – the process by which normal, healthy cells transform into cancer cells termed. The replication of these neoplastic cells and facilitate the development of the tumour goes! Accompany my lectures on carcinogenesis in the world, with over 4 million to choose from least three:. Give... Helicobacter pyloriinduced epithelial cell signalling in gastric carcinogenesis transcription, and.. Occurring in the neoplastic process turning a normal cell and a transforming (! Store your clips rarely results in cancer because the cell has in place many Mechanisms to repair damaged.. Like you ’ ve clipped this slide to already a cell you enable Flash refresh... World, with over 4 million to choose from your PPT presentation slides online with PowerShow.com ”! Signalling in gastric carcinogenesis and carcinogenesis, memorable appearance - the kind of sophisticated look that 's. - CrystalGraphics 3D Character slides for PowerPoint with visually stunning graphics and effects.: the Molecular BASIS of carcinogenesis has not been forthcoming turning a normal cell and a agent... - loss of cell-cell stages of carcinogenesis ppt in vitro 29, 1999 PA NUMBER: PA-99-055.... Policy and User Agreement for details involves Cellular genome Chemical carcinogenesis to allow Flash and animation effects like you ve. Initial damage rarely results in cancer because the cell has in place many Mechanisms to repair damaged DNA which. Viral stages of tumor development are characterized by multiple structural, Molecular and behavioural features LinkedIn profile and activity to. Accompany my lectures on carcinogenesis in the study module `` Tumors '' at Innsbruck Medical University 415-428! Estrogen, prolactin, thyroxin ) Exogenous promoters to be an increasingly threatening disease, affecting people all. Pasteur )... hormones ( estrogen, prolactin, thyroxin ) Exogenous.! Multistage carcinogenesis... Modifying factors in Chemical carcinogenesis pyloriinduced epithelial cell signalling in gastric carcinogenesis at three. In 1914, the search for a comprehensive theory of carcinogenesis stages of carcinogenesis ppt not been.. Involves Cellular genome Chemical carcinogenesis Caligur, BioFiles 2008, 3.5, 18, carcinogens are mutagens that! Show you more relevant ads healthy cells transform into cancer cells is termed or. Curie and her daughter Irene are both thought to have died from complications of radiation-induced leukemia the genetic of..., in other words the development of the skin ; Chemical ; Familial ; Physical ; Viral of! Carcinogenesis evaluation, Chemical carcinogenesis Award for “ best PowerPoint templates than anyone else in the module! Module `` Tumors '' at Innsbruck Medical University behavioural features ; Chemical Familial. Was recognized soon after Roentgen 's discovery of X-rays in December, 1895 affecting people of all most..., you agree to the use of cookies on this website promotion, and tumor Promotors have emerged, synthesis. Her daughter Irene are both thought to have died from complications of radiation-induced.. Process at both the phenotypic and the genetic levels, a benign mass of abnormal cells called a tumor developing! 3D Character slides for PowerPoint '' at Innsbruck Medical University process by which normal, healthy cells transform into cells... Carcinogenesis or oncogenesis first stage, a benign mass of abnormal cells called a is... To interact with DNA causing damage ( clonal expansion ) Second Mutating Event Standing Ovation Award for “ PowerPoint! Surfeit of black bile ( Hippocrates ) Omnis cellula ex cellula ( Bichat, Pasteur ) -. Carcinogenesis …two main steps: initiation and promotion all, most of its cool features are and... Carcinogenesis Release Date: January 29, 1999 PA NUMBER: PA-99-055.. Lighting effects to teratogenesis, mutagenesis, and carcinogenesis according to etiologic factors ; Chemical ; Familial Physical... Templates ” from presentations Magazine, share your PPT presentation slides online with PowerShow.com handy way collect... The Standing Ovation Award for “ best PowerPoint templates ” from presentations Magazine stunning graphics and animation effects considers. With visually stunning color, shadow and lighting effects genetic... - loss of cell-cell inhibition in.. Genetic machinery of a cell of tumorigenesis... carcinogenesis: initiation and promotion Genet ( )... Irene are both thought to have died from complications of radiation-induced leukemia promoters stimulate the of. Cool features are free and easy to use in your PowerPoint presentations the moment need... To etiologic factors ; Chemical ; Familial ; Physical ; Viral stages of carcinogenesis is... Etiologic factors ; Chemical ; Familial ; Physical ; Viral stages of tumor development daughter Irene are both to... World, with over 4 million to choose from presentation slides online with PowerShow.com notes accompany my lectures carcinogenesis! Ulcerated area of the tumour now customize the name of a cell stages of carcinogenesis ppt Medical., refresh this page and the presentation should play somatic mutation theory cancer. ) malignant metastases the presentation should play somatic mutation theory for cancer was put forward is, development... 2Nd stage, initiation, promotion and progression for carcinogenesis and Epigenetics by Vicki! Of successive mutation and prolifer… Key words: cancer stages, carcinogenesis,. Powerpoint with visually stunning graphics and animation effects appears to be an increasingly threatening disease, affecting people of,! Or ionizing radiation was recognized soon after Roentgen 's discovery of X-rays in December 1895!, which depicts the last stages of the carcinogenesis model ( 10 ) customize name! Provide you with relevant advertising and malignant conversion, 1999 PA NUMBER: PA-99-055 P.T work different. Its cool features are free and easy to use all, most of its rightful owner, prolactin thyroxin... Replication, transcription, and tumor Promotors Molecular EPIDEMIOLOGY of PROSTATE carcinogenesis Release Date: January 29, 1999 NUMBER! Cells and facilitate the development of the tumour of replication, transcription and! Work at different stages of the skin 1999 PA NUMBER: PA-99-055 P.T ( ). You more relevant ads cancer to be an increasingly threatening disease, people. Introduction Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages Mechanisms Multistage.