Respiratory System: Respiratory difficulty. Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes. A graded association was noted between baseline level of serum phosphate and the adjusted risk of all-cause mortality, development of heart failure or fatal or nonfatal myocardial infarction, and the composite outcome of fatal coronary disease or nonfatal myocardial infarction (all P for trend=0.03; Figure 1 and Figure 2). Phosphorus's roles are so pervasive that your body literally needs it to survive. In kidney failure, the phosphorus level can become too high. Cardiovascular Disease Hardening of arteries, called atherosclerosis, and calcification of the tissues in the heart due to excess phosphorus levels significantly … It sometimes manifests in chest pain and heart rhythm dysfunction. Participants with serum phosphate ≥4 mg/dL had an adjusted HR for developing heart failure of 1.43 (95% CI, 0.95 to 2.14) compared with those with serum phosphate of 2.5 to 3.4 mg/dL. *Consumption of >7 alcohol units during the 2-week period before enrollment. Although >80% of total body phosphorus is stored in bone and teeth, intracellular phosphorus exists in the form of organic compounds such as adenosine triphosphate and as free anions like H2PO4−, which are commonly referred to as phosphate. Increased blood volume makes it harder for your heart to pump blood around your body. Linus Pauling Institute Micronutrient Center: Phosphorus, University of Maryland Medical Center: Phosphorus, Eastern Michigan University: Control of Blood Pressure, Vitamins & Minerals That Affect the Heart. Tips for Reducing Salt Intake This is for an otherwise healthy person. Healthy kidneys remove extra phosphorus from the blood. Dallas, TX 75231 Phosphate supplements are considered safe if taken as prescribed. The primary outcome for this analysis was all-cause mortality. For instance, participants with serum phosphate ≥3.5 mg/dL had an adjusted hazard ratio for death of 1.27 (95% confidence interval, 1.02 to 1.59) compared with those with serum phosphate of <3.5 mg/dL. Potassium is especially important for your heart's electrical activity, a function that an electrocardiogram, or EKG, records. By continuing to browse this site you are agreeing to our use of cookies. Phosphorus primarily combines with oxygen, as well as other elements, to form phosphates. Dangerous calcium deposits can … Phosphorus' mere involvement in all energy production makes it an indispensable partner to your heart since, like all organs, your heart needs energy in order to function. Despite the importance of phosphate for diverse cellular and physiological functions, little information describes the relation between serum phosphate and clinical outcomes. Third, we cannot exclude the possibility that our findings were influenced by dietary intake of phosphate and thus that dietary habits might confound the association between phosphate and adverse outcomes. Your phosphorus levels can get too high when your kidneys aren’t working correctly. Phosphorus-containing molecules help cells communicate with each other, activate B-complex vitamins and give structure to cell membranes. Contact Us, and for the Cholesterol And Recurrent Events (CARE) Trial Investigators, Correspondence to Dr Marcello Tonelli, University of Alberta, Division of Nephrology and Immunology, 7-129 Clinical Science Bldg, 8440 112 St, Edmonton, Alberta T6B 2B7, Canada. This sudden drop in phosphate level may result in an abnormal heart rhythm and even death. Fatal coronary disease or nonfatal myocardial infarction. Low blood phosphorus, or hypophosphatemia, can also be dangerous. In sensitivity analyses, we adjusted for additional baseline factors found to be associated with serum phosphate levels in the current data set (alcohol use, country of treatment, use of β-adrenergic blockers, systolic blood pressure). Similar findings were noted when the development of new symptomatic heart failure was considered. White phosphorus is a waxy solid which burns easily and is used in chemical manufacturing and smoke munitions. TABLE 2. ACE indicates angiotensin-converting enzyme inhibitor; LDL, low-density lipoprotein; and HDL, high-density lipoprotein. When people are on dialysis phosphorus can build up in the blood because the kidneys no longer work or do not work well. Customer Service In addition, phosphate can bind calcium in the blood, thereby reducing its levels. We used χ2 tests or 1-way ANOVA to test for differences in categorical or continuous factors, respectively, between different categories of serum phosphate. Also, high phosphorus can cause calcium to settle inside the blood vessels. 1-800-AHA-USA-1 Phosphorus' mere involvement in all energy production makes it an indispensable partner to your heart since, like all organs, your heart needs energy in order to function. A significant association was noted between baseline serum phosphate level and the age-, race-, and sex-adjusted risk of all-cause death (hazard ratio [HR] per 1 mg/dL, 1.27; 95% CI, 1.02 to 1.58; P=0.03; Table 3). It can also result in death. However, our study also has some limitations that should be considered. She enjoys researching and writing about health, but also takes interest in family issues, poetry, music, Christ, nature and learning. Baseline Characteristics of Participants By Baseline Serum Phosphate Level. Higher levels of serum phosphate were also associated with increased risk of new heart failure, myocardial infarction, and the composite of coronary death or nonfatal myocardial infarction, but not the risk of stroke. Phosphorus acts as a buffer to help maintain normal acid-base balance. Treatment allocation was concealed with a centrally maintained code. Adjusted Association Between Serum Phosphate Level and Clinical Outcomes. Your heart and lungs are involved in transporting oxygen to your tissues and removing carbon dioxide, and problems with either of these processes affect your breathing. We determined that the proportional-hazard assumption was satisfied by examining plots of the log-negative-log of the within-group survivorship functions versus log-time and by comparing Kaplan-Meier (observed) with Cox (expected) survival curves. The extra stress on the heart and blood vessels can lead to high blood pressure and heart disease. Skin and Appendages: Extravasation necrosis at injection site. Baseline serum phosphate was also independently associated with the risk of coronary death or nonfatal myocardial infarction (P for trend=0.03; Table 3). Probability values for trend are as follows: All-cause death, P=0.03; new congestive heart failure, P=0.03; fatal or nonfatal myocardial infarction, P=0.03; and coronary death or nonfatal myocardial infarction, P=0.03. The normal amount of phosphorus in the blood (also called serum phosphorus) is between 2.5 – 4.5 mg/dL. What Vitamins Increase the Absorption of Minerals in the Body? These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. One reason this can happen is that elevated phosphorus levels reduce your body's ability to make vitamin D, which in turn leads to calcification in your heart's blood vessels. Background— Higher levels of serum phosphate are associated with adverse cardiovascular outcomes, especially in the setting of overt hyperphosphatemia. Some of those functions involve your heart. In addition, when estimated GFR was included in statistical models, neither adjustment for nor stratification on the presence/absence of baseline GFR <60 mL/min/1.73 m2 influenced our results (data not shown). To varying degrees, your cells, tissues and organs all depend on potassium to function normally. Fully adjusted time to clinical outcomes by baseline serum phosphate. As your heart is forced to work harder, it begins to thicken and grow larger. Treatment in the United States (vs Canada). 1-800-242-8721 Interactions. We used Cox proportional-hazards models to examine the association between serum phosphate levels and clinical outcomes. Analyses were performed with Stata 8 SE software. Of 4159 CARE participants, 4127 had serum phosphate measured at baseline and were eligible for this analysis. TABLE 1. Several hormones, including estrogen and adrenaline, also affect phosphorus homeostasis. In addition, we adjusted for multiple potential confounders, including characteristics associated with serum phosphate levels in the current data set. Figure 2. © American Heart Association, Inc. All rights reserved. After categorization based on baseline phosphate level (<2.5, 2.5 to 3.4, 3.5 to 3.9, and ≥4 mg/dL) and further adjustment, a graded independent relation between phosphate and death was observed (P for trend=0.03). Suzanne Fantar has been writing online since 2009 as an outlet for her passion for fitness, nutrition and health. Normal range is 3.7 to 5.2 mEq/L (3.7 to 5.2 mmol/L). Several recent studies demonstrate that higher levels of phosphate are associated with an increased risk of all-cause and cardiovascular death when kidney function is impaired, especially in people with end-stage renal disease.6–9 Vascular calcification has been postulated as the link between hyperphosphatemia and adverse outcomes in the setting of kidney disease, perhaps accelerated by abnormal calcium levels and hyperparathyroidism.5,16 However, unlike participants in the present trial (only 5.2% of whom had hyperphosphatemia at baseline), many of the subjects in these previous studies had overt hyperphosphatemia or were receiving medications that may have influenced the association between serum phosphate and outcome. Covariates for the all-cause death model were used to determine factors associated with adverse cardiovascular outcomes, especially in current. 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